Richard Axel, MD

Richard Axel, MD

Overview

Academic Appointments

  • University Professor

Administrative Titles

  • Co-Director, Mind Brain Behavior Initiative

I am University Professor and Investigator at the Howard Hughes Medical Institute, Columbia University Medical Center. In addition, I am a member of the Departments of Biochemistry and Molecular Biophysics; Neuroscience and the Comprehensive Cancer Center. I obtained an A.B. from Columbia College and an M.D. from Johns Hopkins Medical School. In earlier studies with colleagues Michael Wigler and Saul Silverstein, gene transfer techniques were developed that permit the introduction of virtually any gene into any cell. These studies not only allowed for a novel approach to isolate genes but also provided a detailed analysis of how they worked. At the same time, these experiments allowed for the production of an increasingly large number of clinically important proteins. These studies also led to the isolation and functional analysis of a gene for the lymphocyte surface protein, CD4, the cellular receptor for the AIDS virus, HIV.

I then began to apply molecular biology to problems in neuroscience with the expectation that genetics could interface with neuroscience to approach the tenuous relationship between genes, behavior, and perception. My studies on the logic of the sense of smell revealed over a thousand genes involved in the recognition of odors and provided insight into how genes shape our perception of the sensory environment. My current work centers on how the recognition of odors is translated into an internal representation of sensory quality in the brain and how this representation leads to meaningful thoughts and behavior.

Email: ra27@columbia.edu

Gender

  • Male

Credentials & Experience

Education & Training

  • AB, Molecular Biology, Columbia University
  • MD, Johns Hopkins Medical School
  • Internship: Columbia University
  • Fellowship: Columbia University

Honors & Awards

  • 2004, Nobel Prize in Physiology or Medicine
  • Investigator, Howard Hughes Medical Institute

Research

Mammals possess an olfactory system of inordinate discriminatory power. We are studying how the diversity and specificity of olfactory perception is accomplished. Our analysis of the patterns of expression of the odorant receptor genes, coupled with earlier electrophysiologic experiments have provided a logic for olfactory discrimination. Individual olfactory sensory neurons express only one of a thousand receptor genes. Neurons expressing a given receptor, although randomly distributed in domains in the epithelium, project their axons to a small number of topographically fixed loci or glomeruli in the olfactory bulb. These data support a model of olfactory coding in which discrimination of odor quality would result from the detection of specific spatial patterns of activity in the olfactory bulb.

Research Interests

  • Sensory Physiology
  • Neurogenetics
  • Synapses and Circuits

Grants

THE REPRESENTATION OF INTERNAL STATE IN THE FLY BRAIN (Private)

Jul 1 2017 - Jun 30 2022

SIMONS SOCIETY OF FELLOWS (Private)

Jul 1 2017 - Jun 30 2020

SIMONS SOCIETY OF FELLOWS (Private)

Jul 1 2015 - Jun 30 2018

MECHANISMS OF ASSOCIATIVE LEARNING WITHING OFFACTORY CIRCUITS (Private)

Apr 1 2015 - Mar 31 2018

DEFINING THE CIRCUITRY FOR OLFACTORY MEMORIES BEYOND THE MUSHROOM BODY IN DROSOPHILA MELANOGASTER (Federal Gov)

Jul 1 2015 - Jun 30 2017

EXPERIENCE-DEPENDENT MODULATION OF INNATE NEURAL CIRCUITS (Federal Gov)

Apr 1 2015 - Mar 31 2017

TRANSFORMING A NEURAL REPRESENTATION INTO A MEMORY (Private)

Mar 1 2015 - Aug 31 2016

IMPARTING BEHAVIORAL SPECIFICITY ON CORTICAL REPRESENTATIONS (Private)

Apr 1 2013 - Mar 31 2016

DETERMINE HOW OLFACTORY REPRESENTATIONS IN THE LATERAL ENTORHINAL CORTEX ARE USED BY THE DORSAL HIPPOCAMPUS TO FORM ODOR-PLACE ASSOCIATIONS IN MEMORY (Private)

Apr 1 2011 - Mar 31 2014

ENCODING AND MODULATION OF INNATELY RELEVANT ODOR INFORMATION IN THE MOUSE (Federal Gov)

Sep 1 2008 - Aug 31 2013

THE ARCHITECTURE AND FUNCTION OF A NEURAL CIRCUIT GOVERNING BEHAVIORAL PLASTICITY (Private)

Jul 1 2010 - Jun 30 2013

MOLECULAR APPROACHES TO ALTER OLFACTORY-DRIVEN BEHAVIORS OF INSECT DISEASE VECTORS (Private)

Sep 15 2005 - Mar 31 2013

DEVELOPING OPTOGENETIC TOOLS FOR THE STUDY OF SOCIAL MEMORY (Private)

Jul 1 2009 - Jun 30 2012

Selected Publications

  • 2015 Gore F, Schwartz EC, Brangers BC, Aladi S, Stujenske JM, Likhtik E, Russo MJ, Gordon JA, Salzman CD, Axel R. Neural Representations of Unconditioned Stimuli in Basolateral Amygdala Mediate Innate and Learned Responses. Cell 162(1):134-45. 
  • 2014 Aso Y, Hattori D, Yu Y, Johnston RM, Iyer NA, Ngo TT, Dionne H, Abbott LF, Axel R, Tanimoto H, Rubin GM. The neuronal architecture of the mushroom body provides a logic for associative learning. Elife. 3:e04577. 
  • 2008 Fleischmann, A., B.M. Shykind, D.L. Sosulski, K.M. Franks, M.E. Glinka, D-F., Mei, Y. Sun, J. Kirkland, M., M. Mendelsohn, M.W. Albers, and R. Axel. Mice with a “Monoclonal: Nose": Perturbations in an Olfactory Map Impair Odor Discrimination. Neuron 60:1068-1081.
  • 2008 Datta. S.R., M.L.Vasconcelos, V. Ruta, S. Luo, A. Wong, E. Demir, J. Flores, K. Balonze, B.J.Dickson, and R. Axel. The Drosophila pheromone cVA activates a sexually dimorphic neural circuit. Nature 452:473-477.
  • 2008 Barnea, G., W. Strapps, G. Herrada, Y. Berman, J. Ong, B. Kloss, R. Axel, and K. J. Lee. The genetic design of signaling cascades to record receptor activation. Proc. Natl. Acad. Sci., USA (December 28, 2007, Published Ahead of Print) 105(1) 64-69.
  • 2007 Mancia, F., S. Brenner-Morton, R. Siegel, Z. Assur, Y. Sun, Y, I. Schieren, M. Mendelsohn, R. Axel, and W. Hendrickson. Production and characterization of monoclonal antibodies sensitive to conformation in the 5HT2c serotonin receptor. Proc. Natl. Acad. Sci., USA 104: 4303-4308
  • 2006 Lomvardas, S., G. Barnea., D.J. Pisapia,, and R. Axel. Interchromosomal interaction and olfactory receptor choice. Cell, 126:403-413.
  • 2004 Suh, S.B., A.M. Wong, A.C. Hergarden, J.W. Wang, A. Simon, S. Benzer, R. Axel, and D.J. Anderson. A single population of olfactory sensory neurons mediates an innate avoidance behavior in Drosophila. Nature 431:854-859.
  • 2004 Shah, N.M., D. Pisapia., S. Maniatis, M. Mendelsohn, A. Nemes, and R. Axel. Visualizing sexual dimorphism in the brain. Neuron 43:313-319.