Penelope A. Boyden, PhD

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Overview

Academic Appointments

  • Professor of Pharmacology
Research in our laboratory is dedicated to determining the electrophysiological basis of abnormal heart rhythms (cardiac arrhythmias). In one set of projects we enzymatically isolate single cells from hearts that have become arrhythmic due to experimental myocardial infarction, or pacing induced atrial fibrillation. We examine the function of specific ionic currents, in particular the sodium and potassium currents in the diseased cells and how this might be altered by drugs. In other groups of experiments we use single cells from diseased hearts in order to determine how intracelluar calcium homeostasis is altered in cells of hearts post myocardial infarction. In some studies we combine whole cell voltage clamp techniques with epifluorescent and Ca2+ imaging techniques. We have found examples of reverse excitation contraction coupling where cytosolic Ca2+ elicits nondriven electrical activity (see www.cvr.ucalgary.ca/slideshow for movie example). By studying whole heart and single cell electrophysiology of diseased hearts we can better understand how antiarrhythmic drugs work to terminate and/or prevent cardiac arrhythmias.

Research

Cardiac electrophysiology; mechanisms of arrhythmias in experimental and naturally occurring animal models of disease

Grants

EHD PROTEINS IN CARDIAC MEMBRANE PROTEIN TARGETING AND REMODELING (Federal Gov)

Aug 1 2013 - May 31 2017

PURKINJE CELLS AND ARRHYTHMIA MECHANISMS (Federal Gov)

Apr 1 2011 - Mar 31 2014

PURKINJE CELLS AND ARRHYTHMIA MECHANISMS (Federal Gov)

Apr 1 2011 - Mar 31 2013

ION CHANNEL FUNCTION IN ARRHYTHMOGENIC CARDIAC CELL (Federal Gov)

Dec 1 2000 - Sep 30 2012

THE EFFECTS OF RANOLAZINE ON THREE POTENTIAL PACEMAKERS OF T HE HEART (Private)

Dec 14 2009 - Jun 30 2011

CA2+ WAVES AND ARRHYTHMIAS (Federal Gov)

May 1 1998 - Jun 30 2011

OXIDATIVE STRESS, NA CHANNEL GATING & ARRHYTHMIAS (Federal Gov)

Dec 1 2004 - Nov 30 2007