Larry Abbott, PhD

Larry Abbott, PhD

Overview

Academic Appointments

  • William Bloor Professor of Theoretical Neuroscience
  • Professor of Physiology and Cellular Biophysics (in Biological Sciences)

Administrative Titles

  • Co-Director, Center for Theoretical Neuroscience

Gender

  • Male

Credentials & Experience

Education & Training

  • PhD, Physics, Brandeis University

Honors & Awards

  • 2004  NIH Director’s Pioneer Award
  • 2010  Swartz Prize for Theoretical and Computational Neuroscience
  • 2013  First Annual Prize in Mathematical Neuroscience
  • 2013  Irving Institute Mentor of the Year Award

Research

Computational and Mathematical Analysis of Neurons and Neural Networks

Larry Abbott's research involves the computational modeling and mathematical analysis of neurons and neural networks. Analytic techniques and computer simulation are used to study how single neurons respond to their many synaptic inputs, how neurons interact to produce functioning neural circuits, and how large populations of neurons represent, store, and process information. Areas of particular interest include spike-timing dependent forms of synaptic plasticity, transformations of sensory encoding in olfaction, and the dynamics of internally generated activity and signal propagation in large neural networks.

Most neural activity is generated internally but nervous systems are nevertheless highly sensitive to external influences such as sensory stimuli. We study how stimulus driven and internally generative activity interact and combine to produce responses.  We also model how chaotic ongoing activity can be harnessed and controlled to produce useful motor output.  We are interested in representing perception not as a passive analysis of sensory input, but as a dynamic process that involves modeling the external world, making inferences about predictable events and noting when something unexpected happens.  This requires both representing sensory stimuli and modifying ongoing activity through synaptic plasticity.

Research Interests

  • Theoretical Neuroscience
  • Cognitive/Systems Neuroscience
  • Computation and Theory
  • Neurobiology of Learning and Memory

Grants

ADVANCED GRADUATE TRAINING PROGRAM IN THEORETICAL NEUROSCIENCE (Federal Gov)

Jul 1 2019 - Jun 30 2024

FROM SENSATION TO PERCEPTION: CELLULAR AND CIRCUIT MECHANISMS UNDERLYING PREY DETECTION IN AN ELECTRIC FISH (Federal Gov)

Sep 1 2014 - Aug 31 2017

INTERACTIONS BETWEEN PIRIFORM CORTEX AND AMYGDALA IN A MODEL OF ASSOCIATIVE LEARNING IN THE MAMMALIAN OFFACTORY SYSTEM (Federal Gov)

Aug 1 2014 - Jul 31 2017

HIGHER-LEVEL OLFACTORY PROCESSING (Private)

Jul 1 2014 - Jun 30 2017

NETWORK MODELS FOR TIMING AND SEQUENCE GENERATION (Federal Gov)

May 1 2011 - Feb 28 2017

LEARNING COMPLEX COMPUTATIONS IN MESOSCPIC SPIKING NETWORK (Private)

May 1 2015 - Mar 31 2016

RANDOM CIRCUITS AND REPRESENTATIONS WITHIN STRUCTURED BRAIN AND SPINAL CORD REGIONS SUPPORT FLEXIBLE BEHAVIORS (Private)

Feb 1 2014 - Jan 31 2016

HHMI INTERNATIONAL STUDENT RESEARCH FELLOWSHIP (Private)

Sep 1 2012 - Aug 31 2013

TRANSFORMATION OF SENSORY-MOTOR REPRESENTATIONS BY STATE DEP ENDENT MODULATION (Private)

Oct 1 2008 - Apr 1 2012

NIH DIRECTOR"S PIONEER AWARD (Federal Gov)

Sep 30 2004 - Jul 31 2011

Selected Publications

  • Stern M, Sompolinsky H, Abbott LF. (2014). Dynamics of random neural networks with bistable units. Phys Rev E Stat Nonlin Soft Matter Phys. 90:062710.
  • Aso Y, Hattori D, Yu Y, Johnston RM, Iyer NA, Ngo TT, Dionne H, Abbott LF, Axel R, Tanimoto H, Rubin GM. (2014). The neuronal architecture of the mushroom body provides a logic for associative learning. Elife. 3:e04577.
  • Le Masson G, Przedborski S, Abbott LF. (2014). A computational model of motor neuron degeneration. Neuron. 83:975-988. Erratum in: Neuron. 2014;83:990.
  • Wayne G, Abbott LF. (2014). Hierarchical control using networks trained with higher-level forward models. Neural Comput. 26:2163-2193.
  • Fink, A.J.P., Azim, E., Croce, K.R., Huang, Z.J., Abbott, L.F. and Jessell, T.M. (2014) Presynaptic Inhibition of Spinal Sensory Feedback Ensures Smooth Forelimb Movement. Nature. 509:43-48.
  • Kennedy, A., Wayne, G., Kaifosh, P., Alvina, K., Abbott, L.F. and Sawtell, N.B. (2014)  A Temporal Basis for Predicting the Sensory Consequences of Motor Commands in an Electric Fish.  Nature Neurosci. 17:416-424.Kato, S., Xu, Y., Cho, C., Abbott, L.F. and Bargmann, C. (2014) Temporal Responses of C. Elegans Chemosensory Neurons are Matched to Behavior. Neuron 81:616-628.
  • Schaffer, E.S., Ostojic, S. and Abbott L.F. (2013) A Complex-Valued Firing-Rate Model that Approximates the Dynamics of Spiking Networks. PLoS Comput. Biol. 9:e1003301.
  • Caron, S.J.C, Ruta, V., Abbott, L.F. and Axel, R. (2013) Random Convergence  of Afferent Olfactory Inputs in the Drosophila Mushroom Body. Nature 497:113-117.
  • Babadi, B. and Abbott, L.F. (2013) Pairwise Analysis Can Account for Network Structures Arising from Spike-Timing Dependent Plasticity. PLoS Comput. Biol. 9:e1002906.
  • Monaco, J.D. and Abbott, L.F. (2011) Modular Realignment of Entorhinal Grid Cell Activity as a Basis for Hippocampal Remapping. J. Neurosci. 31:9414-9425.
  • Rajan, K., Abbott, L.F. and Sompolinsky, H. (2010) Stimulus-Dependent Suppression of Chaos in Recurrent Neural Networks. Phys. Rev. E 82:011903.
  • Luo, S., Axel, R. and Abbott, L.F. (2010) Generating Sparse and Selective Third-Order Responses in the Olfactory System of the Fly. Proc. Natl. Acad. Sci. USA 107:10713-10718.
  • Sussillo, D. and Abbott, L.F. (2009) Generating Coherent Patterns of Activity from Chaotic Neural Networks. Neuron 63:544-557.
  • George, M.S., Abbott, L.F. and Siegelbaum, S.A. (2009) Hyperpolarization-Activated HCN Cation Channels Exert Inhibit Subthreshold EPSPs Through Interactions with M-Type K+ Channels. Nature Neurosci. 12:577-584.
  • Vogels, T.P. and Abbott, L.F. (2009) Gating Multiple Signals through Detailed Balance of Excitation and Inhibition in Spiking Networks. Nature Neurosci. 12:483-491.
  • Abbott, L.F. (2008) Theoretical Neuroscience Rising. Neuron 60:489-495.