Emily M. Mace, PhD

Profile Headshot

Overview

Academic Appointments

  • Assistant Professor of Pediatric Immunology (in Pediatrics)

Gender

  • Female

Credentials & Experience

Education & Training

  • Genetics, University British Columbia, Canada

Honors & Awards

2017 American Society for Hematology Junior Scholar Award

Research

Research Interests

  • cell migration
  • primary immunodeficiencies
  • microscopy and image analysis
  • human natural killer cells
  • innate immunity

Grants

DETERMINING THE ROLE OF THE REPLICATIVE HELICASE IN HUMAN NK CELL DEVELOPMENT (Federal Gov)

Sep 24 2018 - Aug 31 2023

DEFINING THE ROLE OF CELL MIGRATION IN HUMAN NK CELL DIFFERENTIATION (Federal Gov)

Jul 2 2018 - Jun 30 2023

ASH SCHOLAR AWARD (Private)

May 15 2018 - Jun 30 2019

Selected Publications

Complete list available here: https://www.ncbi.nlm.nih.gov/pubmed/?term=mace+em

Alfayez M, Wang SA, Bannon SA, Kontoyiannis DP, Kornblau SM, Orange JS, Mace EM, DiNardo CD. Myeloid malignancies with somatic GATA2 mutations can be associated with an immunodeficiency phenotype. Leuk Lymphoma. 2019 Jan 16:1-9. doi: 10.1080/10428194.2018.1551535. [Epub ahead of print] PubMed PMID: 30648453

Chen L, Youssef Y, Robinson C, Ernst GF, Carson MY, Young KA, Scoville SD Zhang X, Harris R, Sekhri P, Mansour AG, Chan WK, Nalin AP, Mao HC, Hughes T, Mace EM, Pan Y, Rustagi N, Chatterjee SS, Gunaratne PH, Behbehani GK, Mundy-Bosse, BL, Caligiuri MA, Freud AG. CD56 Expression Marks Human Group 2 Innate Lymphoid Cell Divergence from a Shared NK Cell and Group 3 Innate Lymphoid Cell Developmental Pathway. Immunity. 2018 Sep 18;49(3):464-476.e4. doi: 10.1016/j.immuni.2018.08.010. Epub 2018 Sep 4. PubMed PMID: 30193847; PubMed Central PMCID: PMC6148384

Mace EM, Orange JS. Emerging insights into human health and NK cell biology from the study of NK cell deficiencies. Immunol Rev. 2019 Jan;287(1):202-225. doi: 10.1111/imr.12725. Review. PubMed PMID: 30565241; PubMed Central PMCID: PMC6310041

Gunesch JT, Angelo LS, Mahapatra S, Deering RP, Kowalko JE, Sleiman P, Tobias JW, Monaco-Shawver L, Orange JS, Mace EM. Genome-wide analyses and functional profiling of human NK cell lines. Mol Imm. 2018. doi.org/10.1016/j.molimm.2018.07.015.

Mace EM. Phosphoinositide-3-kinase signaling in human natural killer cells: new insights from primary immunodeficiency. Front Immunol. 2018 Mar 7;9:445. doi:10.3389/fimmu.2018.00445. 2018.

Carisey AF*, Mace EM*, Saeed MB, Davis DM, Orange JS. Nanoscale Dynamism of Actin Enables Secretory Function in Cytolytic Cells. Curr Biol. 2018 Feb 19;28(4):489-502.e9. doi: 10.1016/j.cub.2017.12.044. Epub 2018 Feb 1. PubMed PMID: 29398219; PubMed Central PMCID: PMC5835143. *Equal contribution

Ruiz-García R, Vargas-Hernandez A, Chinn IK, Angelo LS, Cao TN, Coban-Akdemir Z, Jhangiani SN, Meng Q, Forbes LR, Muzny DM, Allende LM, Ehlayel MS, Gibbs RA, Lupski JR, Uzel G, Orange JS, Mace EM. Mutations in PI3K110δ cause impaired NK cell function partially rescued by rapamycin treatment. J Allergy Clin Immunol. 2018 Jan 9. pii: S0091-6749(18)30026-5. doi: 10.1016/j.jaci.2017.11.042. [Epub ahead of print] PubMed PMID: 29330011.

Lee BJ and Mace EM, 2017. Acquisition of cell migration defines NK cell differentiation from hematopoietic stem cell precursors. Mol Biol Cell. 2017 Oct 11. pii: mbc.E17-08-0508. doi: 10.1091/mbc.E17-08-0508. [Epub ahead of print]

Mace EM, Bigley V, Gunesch JT, Chinn IK, Angelo LS, Care MA, Maisuria S, Keller MD, Togi S, Watkin LB, LaRosa DF, Jhangiani SN, Muzny DM, Stray-Pedersen A, Coban Akdemir Z, Smith JB, Hernández-Sanabria M, Le DT, Hogg GD, Cao TN, Freud AG, Szymanski EP, Savic S, Collin M, Cant AJ, Gibbs RA, Holland SM, Caligiuri MA, Ozato K, Paust S, Doody GM, Lupski JR, Orange JS. Biallelic mutations in IRF8 impair human NK cell maturation and function. J Clin Invest. 2016 Nov 28. pii: 86276. doi: 10.1172/JCI86276

Mace EM, Gunesch JT, Dixon AL, Orange JS. Human NK cell development requires CD56-mediated motility and formation of the developmental synapse. Nat. Commun. 7:12171 doi: 10.1038/ncomms12171 (2016).

Viswanath DI*, Mace EM*, Hsu HT, Orange JS. Quantification of natural killer cell polarization and visualization of synaptic granule externalization by imaging flow cytometry. Clin Immunol. 2016 Mar 3. pii: S1521-6616(16)30031-6. doi: 10.1016/j.clim.2016.03.004. [Epub ahead of print] PMID: 26948929 *Co-first authors. PMID: 26948929

Mace EM, Orange JS. Insights into primary immune deficiency from quantitative microscopy. J Allergy Clin Immunol. 2015 Jun 13. [Epub ahead of print] Review. PMID: 26078103

Angelo LS, Banerjee PP, Monaco-Shawver L, Rosen JB, Makedonas G, Forbes LR,Mace EM, Orange JS. Practical NK cell phenotyping and variability in healthy adults. Immunol Res. 2015 Jul;62(3):341-56. PMID: 26013798

Watkin LB, Jessen B, Wiszniewski W, Vece TJ, Jan M, Sha Y, Thamsen M, Santos-Cortez RL, Lee K, Gambin T, Forbes LR, Law CS, Stray-Pedersen A, Cheng MH, Mace EM, Anderson MS, Liu D, Tang LF, Nicholas SK, Nahmod K, Makedonas G, Canter DL, Kwok PY, Hicks J, Jones KD, Penney S, Jhangiani SN, Rosenblum MD, Dell SD, Waterfield MR, Papa FR, Muzny DM, Zaitlen N, Leal SM, Gonzaga-Jauregui C; Baylor-Hopkins Center for Mendelian Genomics, Boerwinkle E, Eissa NT, Gibbs RA, Lupski JR, Orange JS, Shum AK. COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis. Nat Genet. 2015 Jun;47(6):654-60. PMID: 25894502

Mace EM, Orange JS. Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A.Proceedings of the National Academy of Sciences USA. 2014 Apr 23 (Epub).PMID: 24760828

Mace EM, Orange JS. Visualization of the immunological synapse by dual color time-gated stimulated emission depletion (STED) nanoscopy. J of Vis Exp. 2014 Mar 24;(85) PMID: 24686478

Mace EM, Dongre P, Sinha P, Hsu HT, Watkins LB, Forbes LR, and Orange JS. Cell biological steps and checkpoints in accessing NK cell cytotoxicity. Immunol Cell Biol. 2014 Mar;92(3). PMID: 24445602

Spinner MA, Sanchez LA, Hsu AP, Shaw PA, Zerbe CS, Calvo KR, Arthur DC, Gu W, Gould CM, Brewer CC, Cowen EW, Freeman AF, Olivier KN, Uzel G, Zelazny AM, Daub JR, Spalding CD, Claypool RJ, Giri NK, Alter BP, Mace EM, Orange JS, Cuellar-Rodriguez J, Hickstein DD, Holland SM. GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity. Blood. 2014 Feb 6;123(6):809-21. Epub 2013 Nov 13. PMID: 24227816

Mace EM, Hsu AP, Monaco-Shawver L, Makedonas G, Rosen JB, Dropulic L, Cohen JI, Frenkel EP, Bagwell JC, Sullivan JL, Biron CA, Spalding C, Zerbe CS, Uzel G, Holland SM, Orange JS. Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56bright subset*. Blood. 2013 Apr 4;121(14). PMID: 23365458

Mace EM, Orange JS. New views of the human NK cell immunological synapse: recent advances enabled by super- and high-resolution imaging techniques.Front Immunol. 2012;3:421. PMID: 23316204

Mace EM and Orange JS. Dual channel STED nanoscopy of lytic granules on actin filaments in natural killer cells.Commun Integr Biol. 2012 Mar 1;5(2):184-6. PMID: 22808328

Mace EM, Orange JS. Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A.Proceedings of the National Academy of Sciences USA. 2014 Apr 23 (Epub).PMID: 24760828

Mace EM, Orange JS. Visualization of the immunological synapse by dual color time-gated stimulated emission depletion (STED) nanoscopy. J of Vis Exp. 2014 Mar 24;(85) PMID: 24686478

Mace EM, Dongre P, Sinha P, Hsu HT, Watkins LB, Forbes LR, and Orange JS. Cell biological steps and checkpoints in accessing NK cell cytotoxicity. Immunol Cell Biol. 2014 Mar;92(3). PMID: 2444560

Mace EM, Hsu AP, Monaco-Shawver L, Makedonas G, Rosen JB, Dropulic L, Cohen JI, Frenkel EP, Bagwell JC, Sullivan JL, Biron CA, Spalding C, Zerbe CS, Uzel G, Holland SM, Orange JS. Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56bright subset*. Blood. 2013 Apr 4;121(14). PMID: 23365458

Mace EM, Orange JS. New views of the human NK cell immunological synapse: recent advances enabled by super- and high-resolution imaging techniques.Front Immunol. 2012;3:421. PMID: 23316204